Dongjie Sun

ADAM17 is a broad HIV-1 restriction factor targeted by Nef to restore Env maturation

HIV-1 uses the accessory protein Nef to enhance the infectivity of newly produced virus particles, but the host defenses counteracted by Nef remain incompletely defined. The membrane protein SERINC5 contributes to this defense but primarily restricts laboratory-adapted HIV-1 stra...