Dong Xue

Practical synthesis of 3-Oxa/Aza-bicyclo[3.1.1]heptanes from 3-Oxa/Aza[3.1.1]propellanes

While bicyclo[1.1.1]pentanes (BCPs) and bicyclo[3.1.1]heptanes (BCHeps) serve as established 3D bioisosteres for para- and meta-substituted benzenes, accessible via ring-opening of their corresponding propellanes, the integration of heteroatoms into these propellane scaffolds has...