Dong-Xiao Lou

Intranasal delivery of BDNF-enriched small extracellular vesicles ameliorates cognitive impairment and Alzheimer’s disease-like pathology in APP/PS1 mice

Alzheimer’s disease (AD), the leading cause of dementia, still lacks broadly effective disease-modifying therapies. Here, we engineered brain-derived neurotrophic factor (BDNF)-enriched small extracellular vesicles (BDNF-sEVs) from human induced pluripotent stem cell-derived mese...