Dong-Seok Lee

Dual-mode SOX2 regulation by miR-150 via mRNA suppression and autophagy controls stem cell fate

Autophagy plays a critical role in maintaining cellular homeostasis and regulating stem cell fate. Although microRNAs (miRNAs) are being increasingly recognized for their ability to modulate autophagy and pluripotency in human pluripotent stem cells (hPSCs), the underlying molecu...