Dong Lu

Establishment of an enteral nutrition pathway for malignant esophageal obstruction using combined esophageal stenting and gastrostomy

Malnutrition is common in patients with advanced esophageal cancer and is associated with poor outcomes. While esophageal stenting can relieve dysphagia, oral intake alone is often insufficient. Percutaneous endoscopic gastrostomy (PEG) provides reliable nutritional support but d...

Discovery andDevelopment of First-in-Class Cereblon-RecruitingRIPK1 Degraders

Abstract Receptor-interacting protein kinase 1 (RIPK1) is a critical regulator of programmed cell death and is implicated in various pathological conditions, particularly in mediating tumor resistance to immune checkpoint inhibitors (ICIs). In this study, we have pioneered the de...