Dong-Gyu Heo

Application of Physiologically Based Pharmacokinetic Modeling to Optimize Assessment of Age‐Related Fluoxetine Accumulation in the Elderly

ABSTRACT This study quantified age‐related differences in fluoxetine pharmacokinetics and evaluated the influence of CYP2D6 phenotype using physiologically based pharmacokinetic (PBPK) modeling integrated with clinical therapeutic drug monitoring data. A PBPK model for fluoxetine...