Dirk C. Hoffmann

Decoding the regulatory programs governing glioblastoma plasticity

Abstract Glioblastoma is incurable and resistant to therapy despite genomic stability under treatment 1–8 , suggesting that non-genetic cellular plasticity is a central driver of progression. Whether such plasticity reflects stochastic state switching or is governed by predictabl...

Mocetinostat Shows Network-Inhibitory Effects on Glioblastoma Cells, Enhancing Radiotherapy Efficacy

Abstract Purpose Glioblastoma cells use neurite-like extensions, called tumor microtubes (TMs), as intercellular connections to integrate into a communicating network that contributes to glioblastoma’s high therapy resistance. Understanding the biological functions of tumor cell...