Dimitra Koumaki

Is Exposure to Certain Endocrine-Disrupting Chemicals Associated with Increased Skin Cancer Risk?

Background/Objectives: This review investigated whether exposure to certain endocrine-disrupting chemicals (EDCs) increases skin cancer risk. Methods: We performed a comprehensive narrative review of in vitro, animal, and human studies examining the association of EDCs with melan...

Diagnostic Performance of the Lymphocyte Transformation Test and Patch Testing in Delayed Hypersensitivity Drug Reactions

Background: Cutaneous adverse drug reactions (CADRs) occur in 2–5% of inpatients, primarily due to delayed (T-cell-mediated) reactions, such as maculopapular exanthemas (MPEs). The lymphocyte transformation test (LTT) detects drug-specific T-cell responses with varied sensitivity...

Dermatologic Toxicities Associated with Tebentafusp for Uveal Melanoma: A Review of Clinical Trials and Real-World Evidence

Tebentafusp is a first-in-class bispecific fusion protein that redirects T cells toward gp100-expressing cells and represents the first systemic treatment shown to improve overall survival in patients with HLA-A*02:01-positive metastatic uveal melanoma. As gp100 is also expressed...