Diego A. Chiappetta

Mannose-Functionalized Polymeric Micelles Target CD206-Expressing Macrophages Within Human Tuberculosis Granulomas and Improve Isoniazid Delivery

Background: Latent tuberculosis infection (LTBI) remains a global health challenge, in part due to the ability of Mycobacterium tuberculosis (Mtb) to persist within granulomatous lesions where drug exposure may be limited. Because granulomas are heterogeneous structures composed...