Dian Chen

Kinetic-Gated Signal Transduction Decouples Binding Affinity in a Dual-Pocket Riboswitch RNA

Abstract RNA has emerged beyond its traditional biological role to become a premier biorecognition element in biosensor design. While single-target RNA sensors demonstrate high specificity, multi-pocket variants, such as the tetrahydrofolate (THF) riboswitch, enable complex signa...