Dhirendra S. Katti

A validated IL1β-induced caprine ex vivo early osteoarthritis model reveals disease-modifying efficacy of TC-S 7009 via HIF-2α inhibition

Osteoarthritis (OA) is a debilitating multifactorial joint disease lacking effective disease-modifying OA drugs (DMOADs). High failure rates for clinical trials in OA could be due to inadequate screening approaches that rely on single target strategies and late-stage disease mode...