Devjanee Swain Lenz

Engineered pediatric human muscle models the interferon-driven transcriptome of juvenile dermatomyositis

Abstract Juvenile dermatomyositis (JDM) is a rare pediatric autoimmune disease characterized by a strong type I interferon (IFN) signature in muscle. Mechanistic and therapeutic discovery has been limited by the lack of a clinically relevant disease model. To address this, we tes...