Deren Demirel Yavuz

miR-548ah-3p suppresses ovarian cancer stemness and therapeutic resistance through network-level signaling reprogramming within a distinct alternative polyadenylation landscape

Abstract Therapeutic resistance and cellular plasticity remain major challenges in high-grade serous ovarian cancer (HGSOC), yet the RNA-mediated mechanisms sustaining stem-like states remain incompletely understood. Here, we investigated microRNA-driven signaling reprogramming a...