Author
Denise Reeves
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Recent research
- BiologyOpen access
Werner helicase inhibitor for advanced microsatellite instability solid tumors: a phase 1 trial
Abstract Werner syndrome helicase (WRN) is a synthetic lethal target for microsatellite instability (MSI) cancers. In part 1 of this ongoing first-in-human, phase 1 trial, escalating doses of RO7589831 (VVD-133214), a first-in-class, WRN covalent inhibitor, were evaluated in 88 p...