Dengchao Zhu

Integrative AI-assisted modeling suggests CPPF binding at a composite α/β-tubulin interface pocket dominated by β-tubulin contacts

Microtubules are dynamic cytoskeletal polymers assembled from α / β -tubulin heterodimers. Microtubules are validated targets for novel therapeutic drugs, yet therapeutic efficacy targeting them is often compromised by multidrug resistance (MDR). 5-(3-chlorophenyl)-N-(3-pyridinyl...