DeNard Simmons

Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in substantia nigra

Recent studies have implicated dopaminergic signaling within the substantia nigra pars reticulata (SNr) in the emergence of Parkinsonian motor deficits. To better understand the mechanisms underlying this dependence, the ability of dopamine to modulate SNr neuron activity was stu...