Deanna M. Barch

Multimodal Prediction of Distressing and Persistent Psychotic-Like Experiences in Adolescence across Environment, Genetics, and Neuroimaging

Adolescent psychotic-like experiences, particularly those that are distressing and persistent (dpPLEs), may elevate risk for a range of psychiatric disorders, yet the relative predictive contributions of brain structure, genetics, and environment to dpPLEs remain unknown. Using f...

Maternal Depression, Childhood Resting‐State Brain Connectivity, and Adolescent Depression During the COVID‐19 Outbreak

Adolescents of mothers with a history of depression are at increased risk for developing depression themselves. These adolescents may have been especially vulnerable to depression under conditions of stress, such as the beginning of the COVID-19 pandemic. To understand the comple...

Modeling decision dynamics disentangles working memory, cognitive control and reinforcement learning and reveals clinical differences

Various neurocognitive processes contribute to reinforcement learning (RL) and decision making, requiring careful task designs and computational modeling to disentangle them. People rely on capacity-limited working memory (WM) to rapidly and flexibly adapt behavior during learnin...

Toward actionable biomarkers in psychiatry: a collaborative roadmap for precision clinical trials. An ACNP position paper

Abstract Psychiatric drug development remains constrained by diagnostic heterogeneity, insufficient and inconsistent drug response, high placebo response rates, and the absence of validated biomarkers that can reliably guide patient stratification, trial design, and regulatory de...