Dean Joseph Tantillo

Non‐metal Lewis Acid‐Catalyzed Reduction of Phosphine Oxides with Silanes: Mechanistic Study and Reaction Optimization

Non-metal Lewis acid (NM LA)-catalyzed silane-mediated reductions represent an important strategy for the conversion of phosphine oxides to phosphines. Although a variety of catalytic systems have been developed, their underlying reaction mechanisms remain insufficiently understo...

Synthesis, Evaluation, and Context for Applications of SF5-Containing [1.1.1]Bicyclopentane and [ 2 ]Staffane “Hybrid Bioisosteres”

Abstract Bioisosteric replacements are conventionally applied as single-variable changes to a parent molecule during drug discovery campaigns. Herein, we evaluate hybrid bioisosteric replacements as strategic combinations of multiple substitutions that counterbalance the physicoc...