David W. Hein

CRISPR/Cas9 knockout of N-acetyltransferase 1 influences mesenchymal transition in glioblastoma in a cell line dependent manner

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and carries a poor prognosis despite standard of care treatment with surgical debulking, chemotherapy, and radiotherapy. Proneural to mesenchymal transition (PMT) is a key driver of GBM invasion and tre...