David Sperry

Image-Based Quantification of Amorphous Solid Dispersion Tablet Formulation Disintegration Profiles in a Custom USP-2 Apparatus

Abstract Amorphous solid dispersions (ASDs) are single-phase molecular mixtures of amorphous drug and polymer designed to enhance solubility, inhibit crystallization, and improve release rate, increasing bioavailability. During dissolution, water lowers the glass-transition tempe...