David Sack

Influence of gut microbiota on immune responses and protection in volunteers receiving the live attenuated oral ETEC vaccine ACE527 followed by virulent ETEC H10407 challenge

Enterotoxigenic Escherichia coli (ETEC) remains a major cause of diarrheal morbidity with no licensed vaccines. Role of gut microbiota in vaccine immunogenicity and protection was investigated using 16 S rRNA sequencing from the stool samples of 27 volunteers receiving two doses...