David P. Marciano

Endothelial Redox Dysregulation in Pulmonary Arterial Hypertension: Compartmentalized Mechanisms and Therapeutic Implications

Pulmonary arterial hypertension (PAH) is a progressive pulmonary vasculopathy in which endothelial dysfunction drives increased pulmonary vascular resistance and arterial remodeling. Redox signaling is central to endothelial homeostasis, and its disruption in PAH reflects changes...