David M. Virshup

EPHA2 and WNT reciprocally regulate MAPK-dependent gene expression in a pancreatic cancer model

Wnt signaling drives tumorigenesis in multiple cancers, in part through complex interactions with other oncogenic pathways including the MAPK cascade. In Wnt-addicted cancers, pharmacologic and genetic inhibition of Wnt signaling activates multiple receptor tyrosine kinases (RTKs...