David Lu

On Central Immunological Tolerance Defects and Oncogenesis: A Closed-Loop Deduction Based on the X+n/X−n Thymic Selection and Immune Surveillance Model

Traditional oncology often posits environmental exposure and gene mutations as the primary causal factors in cancer development. However, epidemiological paradoxes—such as the high cancer incidence in countries with pristine natural environments, significant age-standardized inci...

On Central Immunological Tolerance Defects and Oncogenesis: A Closed-Loop Deduction Based on the X+n/X−n Thymic Selection and Immune Surveillance Model

Traditional oncology often posits environmental exposure and gene mutations as the primary causal factors in cancer development. However, epidemiological paradoxes—such as the high cancer incidence in countries with pristine natural environments, significant age-standardized inci...