David Ledingham

Evaluating the Interaction of Alzheimer Biomarker Burden and α-Synuclein Status on Cognitive Trajectories in Parkinson Disease: Methodological Challenges and Power Estimates

Background: Alzheimer disease (AD) and α-synuclein copathology frequently co-occur in Parkinson disease (PD), but whether their interaction accelerates longitudinal cognitive decline is unknown. Objective: To investigate whether the cross-sectional interaction between AD biomarke...