David L. Hughes

Synthesis and evaluation of fluorinated chromene-pyridone as a dual-acting agent against Alzheimer's disease and cancer: biological assessment and computational modelling

The global challenge of neurodegenerative diseases and cancer necessitates new multifunctional therapeutics. We designed and synthesised novel chromene-hydrazone derivatives as multitarget ligands. Structures were confirmed spectroscopically and by X-ray crystallography, with dat...