David J. Wales

The AML-Associated A338V Mutation Rewires GPR183 Signaling through C-Terminal Ensemble Redistribution

Abstract G protein–coupled receptors (GPCRs) rely on dynamic conformational ensembles to coordinate G protein activation and recruitment of regulatory transducers such as GPCR kinases and β-arrestins. The oxysterol receptor GPR183 has been implicated in hematological malignancies...

Real-Space Imaging of Thomson Charge Configurations in Superfluid Helium Nanodroplets

Predicting the lowest-energy arrangement of like charges on a sphere defines the Thomson problem, a long-standing challenge with analytical solutions only for a few small systems. We report a real-space experimental realization using superfluid helium nanodroplets, where surface-...