David J. Pocalyko

Identification of a novel dependency between PRMT5 and APC-LOF in preclinical models of FAP disease

Strategies for targeting adenomatous polyposis coli ( APC) loss-of-function ( APC -LOF) may provide an opportunity to intercept tumorigenesis in high-risk CRC patients, such as those with Familial Adenomatous Polyposis (FAP). Here, we uncovered a novel synthetic lethal dependency...