David J. Irwin

Activated microglial phenotypes in the hippocampal CA2 subfield are implicated in Lewy body disease progression

Abstract Histopathologic staging models of neuronal α-synuclein pathology (n-asyn) in Lewy body disease (LBD) seldom evaluate brain regions with direct synaptic connectivity to model the role of microglial processes. We address this gap by testing the hypothesis that, within the...