David J. Fulton

Therapeutic Targeting of the Macrophage YTHDC1/TIGAR/NF-κB Axis Mitigates Pulmonary Hypertension

Abstract Rationale Immune dysregulation is a pivotal driver of pulmonary hypertension (PH) pathogenesis, yet therapeutic targeting of inflammation has yielded limited clinical success. Although cytosolic RNA-binding proteins are known to regulate immune responses in PH, the speci...