David Crich

Synthesis of 1,3-Dihydro-2,1-benzisoxazoles by Intramolecular C–N Coupling: Evaluation as an Indane Bioisostere

Abstract Despite the ever-increasing interest in isoxazole-based compounds, benzo-fused isoxazolidines, or 1,3-dihydro-2,1-benzisoxazoles, are very rare. Seeking to fill this gap, we present a method for the synthesis of 1,3-dihydro-2,1-benzisoxazoles by intramolecular Cu-mediate...

Energeticsof Formation and Fragmentation of Carbon-CenteredRadicals α- to Nitrogen and Oxygen in N , N , O -Trimethylhydroxylamine in Comparisonto Trimethylamine and Dimethyl Ether: Implications for Medicinal andSynthetic Chemistry

Abstract α–C–H bond dissociation energies (BDEs) have been computed for N,N,O-trimethylhydroxylamine, trimethylamine, and dimethyl ether, leading to the conclusion that there is no advantage to hydrogen abstraction from trisubstituted hydroxylamines over the corresponding tertiar...