David C. Rubinsztein

G3BP1 depletion, observed in Parkinson’s Disease, drives Golgi–lysosome–autophagy defects

Abstract The RNA binding G3BP1 is depleted in several neurodegenerative diseases, yet its functional consequences at the cellular level remain poorly understood. While best known for its critical role in stress granule formation, we demonstrate that G3BP1 also stabilises the COPI...