David Aebisher

Artificial Intelligence in Photodynamic Therapy: From Molecular Design of Photosensitizers to Intelligent Delivery, Adaptive Dosimetry, and Personalized Prognostication of Results

Photodynamic therapy (PDT) is a minimally invasive therapeutic approach based on the light-induced activation of a photosensitizer in the presence of molecular oxygen, resulting in the generation of reactive oxygen species, including singlet oxygen. Despite local selectivity and...

Spectroscopic Evidence of Free Radicals Generated by Indocyanine Green Under Light Irradiation

Reactive oxygen species (ROS), particularly free radicals involved in type I photodynamic mechanisms, are key mediators of photodynamic therapy. Indocyanine green (ICG), a clinically approved near-infrared dye, is increasingly being considered as a photosensitizer. It has attract...

MALDI Mass Spectrometry Imaging in Alzheimer’s Disease Lipidomics: Matrix Selection, Spatial Lipid Pathology and Emerging Analytical Strategies

Alzheimer’s disease (AD) involves not only amyloid-β and tau pathology but also extensive disturbances in lipid metabolism, membrane organization, neuroinflammatory signaling, and tissue homeostasis. Conventional lipidomics has identified changes in phospholipids, sphingolipids,...