Darren Boehning

DHHC21 is a STIM1 protein S-acyltransferase that modulates immune function in vivo

Depletion of calcium from ER stores leads to the activation of calcium channels on the plasma membrane known as store-operated calcium entry. The proteins STIM1 and STIM2 function as ER calcium sensors, and upon store depletion, they undergo a conformational change that allows th...