Darko Stojkov

HMGB1 expression in CT26 murine cancer cells modulates the tumor microenvironment and limits local anti-tumor immunity

Abstract High mobility group box protein 1 (HMGB1) is a ubiquitous protein that has multiple functions in the nucleus and cytosol. Following release into the extracellular space, HMGB1 acts as a mediator of inflammation. HMGB1 is overexpressed in many cancers and has both oncogen...

Empagliflozin in GSD-Ib: Long-term safety and sustained recovery of neutrophil function including NET formation

Glycogen storage disease type Ib (GSD-Ib) engenders neutropenia and severe neutrophil dysfunction, leading to recurrent infections and inflammatory complications. Recent studies have identified intracellular accumulation of 1,5-anhydroglucitol-6-phosphate (1,5-AG6P) as a key mech...