Daolin Tang

Engineering microRNAs as multimodal cancer therapeutics

Resistance to systemic therapy remains a major challenge in non-small cell lung cancer (NSCLC). Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have improved outcomes for patients with EGFR-mutant tumors, but acquired resistance is common and can arise t...

Autophagic degradation of RAB8A promotes ferroptosis through dysregulation of TFRC-mediated iron uptake

Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation; however, how selective autophagy regulates ferroptotic sensitivity remains incompletely understood. Here, we identify RAB8A as a selective autophagic substrate and negative regulator of fe...

Cuproptosis: an emerging member of the immunogenic cell death family

Cell death was long considered the terminal consequence of cellular stress or damage, and distinct cell death modalities were classified according to their molecular execution mechanisms rather than their immunological impact [ 1 , 2 ]. This reductionist view has progressively be...