Danyang Li

Structural and Mechanistic Insights Into GSDME Pore Formation and Functional Regulation

ABSTRACT Gasdermin E (GSDME) is a unique member of the gasdermin family linked to deafness, cancer, and neurodegenerative diseases, and mediates chemotherapy‐induced pyroptosis; however, its pore‐forming mechanism remains poorly understood. Here, we present cryo‐EM structures of...

Actin‐Related Causes of Aneuploidy in Human Eggs

Gametogenesis (oogenesis and spermatogenesis) relies on a specialized form of cell division known as meiosis. During this process, chromosomes in parental cells undergo two successive rounds of segregation, resulting in a halving of their number and the formation of haploid germ...