Danielle van Westen

Cognitive impairment, medial temporal lobe changes, and fluid biomarkers of Alzheimer’s disease and neurodegeneration following herpes simplex virus type 1 encephalitis

Abstract Background Herpesvirus encephalitis is a severe brain infection, in adults most often caused by herpes simplex virus type 1 (HSV-1). It predominantly affects the medial temporal lobes (MTL), which are critical for memory functions. Links have been discussed between herpe...

Early post-contrast signal changes in CSF spaces and CSF outflow-related regions on 7 Tesla MRI

Abstract Brain fluid exchange can be studied in vivo with post-contrast MRI, but serial semiquantitative 7 T heavily T2-weighted FLAIR data in healthy adults remain limited. In this prospective study, we characterized post-contrast signal kinetics in CSF spaces and CSF outflow-re...