Daniel R. Southworth

Cofactor-Free Tau FilamentsAre Dynamic and UndergoStructural Evolution Driven by Thermodynamic Control

Abstract Tau filaments are a hallmark of neurodegenerative tauopathies, such as Alzheimer’s disease (AD). Structural studies have revealed that patient-derived tau fibrils adopt distinct folds in different tauopathies; however, it is unclear what forces guide this process. To exp...