Daniel Levey

POWER, REPLICATION, AND EPIGENETIC SIGNAL IN PSYCHIATRIC DISORDERS: CONTRASTING METHYLOME-WIDE ASSOCIATION STUDIES OF MAJOR DEPRESSIVE DISORDER AND GENERALIZED ANXIETY DISORDER IN THE MILLION VETERAN PROGRAM

Epigenome-wide association studies (EWAS) of psychiatric disorders have historically been limited by modest sample sizes, contributing to inconsistent findings and poor replication. Leveraging DNA methylation data from the Million Veteran Program (MVP), we conducted large-scale m...

27. EPIGENOME-WIDE ANALYSIS REVEALS DISTINCT DNA METHYLATION PROFILES FOR OPIOID DEPENDENCE VERSUS OPIOID EXPOSURE

Background The U.S. opioid epidemic represents a serious public health crisis. While epigenetic mechanisms have been linked to opioid use disorder (OUD), more research is needed to identify actionable biomarkers that distinguish opioid exposure from opioid dependence. In this stu...

MULTI-ANCESTRY GWAS OF GENERALIZED ANXIETY DISORDER IN THE MILLION VETERAN PROGRAM

Generalized anxiety disorder (GAD) remains underpowered in genetic studies relative to other psychiatric traits. We conducted a multi-ancestry genome-wide association study (GWAS) of GAD in the Million Veteran Program (MVP), including 42,130 cases and 580,993 controls across Euro...