Daniel Kirchhofer

Discovery ofHighly Selective Noncovalent MacrocyclicPeptide Inhibitors Suppressing Both TMPRSS2 Protease Activity andViral Receptor Function

Abstract The type II transmembrane serine protease TMPRSS2 plays a critical role in respiratory virus entry, including SARS-CoV-2. Using an mRNA display platform with genetic code reprogramming, we identified macrocyclic peptide (MCP) inhibitors of TMPRSS2 that bound to the TMPRS...