Daniel E. Kahne

Structural basis for regulating lipopolysaccharide transmembrane transport

Gram-negative bacteria are surrounded by a multilayered cell envelope with a mostly impermeable outer membrane that provides intrinsic resistance to many antibiotics1–5. The outer membrane is an asymmetrical bilayer with phospholipids in the inner leaflet and lipopolysaccharide (...

Activation of the angiotensin II type I receptor by a nonpeptide agonist

The angiotensin II type I receptor (AT1R) is a G protein–coupled receptor that regulates the cardiovascular system and as a result is one of the most successful pharmacological targets for the treatment of hypertension. Within the angiotensin receptor pharmacological landscape, a...