Daniel J. Wozniak

Mucin promotes Psl production and surface exploration in Pseudomonas aeruginosa

ABSTRACT In chronic, recalcitrant infections, Pseudomonas aeruginosa forms biofilm aggregates that are encapsulated in a protective extracellular matrix made of exopolysaccharides, extracellular DNA, and matrix proteins. Biofilm formation is a major cause of antibiotic clearance...

Efficacy of Antibiotic-Loaded Stimulan Beads Against Biofilms on Clinically Relevant Orthopedic Implant Surfaces

Background: Bacterial biofilms play a key role in causing periprosthetic joint infection (PJI). Current PJI management strategies commonly combine systemic antibiotic therapy with localized delivery such as antibiotic-loaded cement or beads to achieve effective tissue penetration...