Daniel J. Breiner

Evaluating the Effect of Chromatographic Chelator Modifiers on Metabolite Levels in Untargeted Liquid Chromatography–Mass Spectrometry

Abstract Metal-sensitive metabolites frequently exhibit poor chromatographic performance during liquid chromatography–mass spectrometry (LC-MS) due to analyte interactions with stainless-steel components of the chromatographic system. Although mobile phase chelators are widely us...