Daniel Brösamlen

Nickel-Catalyzed Enantio- and Regioconvergent Synthesis of Allyl Aryl Thioethers from α- or γ-Silylated Allylic Chlorides

An enantio- and regioconvergent allylic substitution of non-symmetrical 1,3-disubstituted allylic chlorides with thiophenols under nickel catalysis is reported. The use of 18-crown-6 as an additive is crucial for obtaining good yields. Despite competing uncatalyzed nucleophilic d...