Daniel A. Fletcher

Actin conformation dynamics precede force generation in cytotoxic T lymphocytes

Abstract Cytotoxic T lymphocytes (CTLs) are cells of the adaptive immune system that are able to recognise and kill cancerous or virally infected target cells. The biochemical basis of CTL-mediated killing has been examined in great detail. Recent work has underscored the importa...

A multi-site loiasis dataset of whole blood videos

Loiasis is a blood-borne filarial infection under consideration for inclusion in the WHO’s priority list of Neglected Tropical Diseases. In addition to its direct impact on human health, loiasis frequently occurs as a co-infection with other filarial diseases, including onchocerc...