Dandan Chen

Integrative transcriptomic and single-cell analysis identifies anoikis-related molecular signatures in vascular calcification

BACKGROUND: Vascular calcification (VC) is a life-threatening complication of chronic kidney disease (CKD) driven by vascular smooth muscle cell (VSMC) osteogenic transdifferentiation. Anoikis, a form of adhesion-dependent apoptosis, is involved in cardiovascular remodeling, yet...