Dale Ian Godfrey

In Vivo Blood Kinetics and Transcript Integrity of Three mRNA–Lipid Nanoparticle Vaccines in Humans

Abstract mRNA–lipid nanoparticle (LNP) vaccines are detectable in human blood after vaccination, but platform-specific differences in systemic persistence and transcript integrity remain poorly defined. We analyzed serial blood samples from 73 participants receiving Moderna mRNA-...

Specific targeting of MR1-antigen complexes using nanobodies

T cell receptor mimic (TCRm) antibodies that bind peptide–human leukocyte antigen complexes have great therapeutic potential. Major histocompatibility complex class I–related protein 1 (MR1) exhibits limited polymorphism and presents conserved metabolites, such as 5-OP-RU, derive...