Daigoro Hirohama

Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1 ‐Dependent Suppression of ROMK

ABSTRACT Aim Hyperkalemia is prevalent in the elderly, and underlying molecular mechanisms remain incompletely understood. We hypothesized that Klotho deficiency, a feature of aging, impairs renal potassium homeostasis and contributes to hyperkalemia. Methods Klotho heterozygous...

Integrated morphological and transcriptomic analysis of bone disorders in aldosterone-salt hypertension

Abstract Although excessive dietary sodium intake is a well-recognized risk factor for hypertension, accumulating evidence indicates that it leads to broader metabolic consequences. Here, we investigated the renal and skeletal consequences of high salt loading and the protective...