D Mondal

Phenylalanine Fibrils Seed Native Lysozyme to Form Membrane-Active Pathological Complexes at Physiological Conditions

Abstract Accumulation of metabolites at pathological concentrations can trigger nonclassical protein aggregation pathways that remain poorly understood. Here, we explore the molecular mechanism by which the metabolite phenylalanine (Phe), known to form amyloid-like fibrils in Phe...